177 GAL GLC CAT_SITE
283 GAL GLC CAT_SITE

Domenico: Swissprot molecula rfunction for this target is aldose 1-epimerase and carbohydrate binding activities. Residues His177, Glu283 and Asp230 form the catalytic site, while Asn73 and Arg74 are incolved in binding, based on information transfer from similar proteins.
Genthreader most confident hit is 1snzA0 but has no valid ligands bound, but there's an alternative structure solved for the same protein - 1SO0 - bound to galactose. Other residues in the target could contact the ligand based on Ligplot data for that structure. However, only His101 is stronly conserved and close to the binding region.

PFRMAT FN
TARGET T0524
AUTHOR 7656-5034-1890
REMARK Sequence consensus of contacts between homologous structures and ligands
METHOD pGenTHREADER and PDBSum and CSA data mining.
MODEL 1
Binding site: 73, 74, 177, 230, 283
END

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« This page (revision-1) was last changed on 27-May-2010 15:14 by UnknownAuthor