Domenico:
Unfortunately contacts from Genthreadre's hits are not useful, being invalid from a biological standpoint. However, homologues 2hbwA0 and 2evrA0 appear to be gamma-D-glutamyl-l-diamino acid endopeptidases, based on literature.
In "Structural Basis of Murein Peptide Specificity of a gamma-D-Glutamyl-L-Diamino Acid Endopeptidase" (Structure 2009) the authors show that the catalytic triad Cys-His-His is well conserved between 2fg0A and 2hbwA and conduct experiment to support the molecular function of 2hbw. Those residues are also identically conserved in our manual model based on Dali alignments. Consequently I would submit

PFRMAT FN
TARGET T0565
AUTHOR 7656-5034-1890
REMARK Sequence consensus of contacts between homologous structures and ligands
METHOD pGenTHREADER and PDBSum and CSA data mining
MODEL 1
Binding site: 203, 263, 275
END

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« This page (revision-1) was last changed on 15-Jun-2010 13:46 by UnknownAuthor