Domenico:
This target is likely to belong to the large and functionally diverse ?/? sandwich family of metallo-dependent phosphoesterases. However, the target does not match the canonical sequence motif of glycerophosphodiesterases, which includes the active site residues. Besides, most PDBSum contacts correspond to invalid ligands and there's no structure in complex with the relevant substrate or an analogue. As members of this family have displayed catalytic activity divalent and trivalent metal ions, I'd suggest to submit a consensus of the contacts inherited from Genthreadre's hits with Calcium, Zinc and Magnesium - Glu59, Asp61 and Glu123.

PFRMAT FN
TARGET T0570
AUTHOR 7656-5034-1890
REMARK Sequence consensus of contacts between homologous structures and ligands
METHOD pGenTHREADER and PDBSum and CSA data mining
MODEL 1
Binding site: 59, 61, 123
END

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« This page (revision-1) was last changed on 21-Jun-2010 15:15 by UnknownAuthor