Domenico:
This target is likely to catalyze the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in cell-wall glycopeptides. Zinc is catalitycally active, so we should submit those contacts only. However, the mapping we obtained is affected by some shifts in the alignments and so gives an unreliable prediction - Gly12 would be involved in ion binding for instance. Also, the low number of valid interactions is low, which increases the chances of false positives. Based on literature data, residues His11, Glu27, His80, and Glu142 in xovA0 coordinate Zinc, but the second one is misaligned. I'd suggest to predict His13, Glu28 and His82.

PFRMAT FN
TARGET T0585
AUTHOR 7656-5034-1890
REMARK Sequence consensus of contacts between homologous structures and ligands
METHOD pGenTHREADER and PDBSum and CSA data mining.
MODEL 1
Binding site: 13, 28, 82
END

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« This page (revision-1) was last changed on 29-Jun-2010 10:11 by UnknownAuthor