Domenico:
The N-terminal domain belongs to the beta lactamase family. The active site is made up of Asp60 only. In addition, this site requires Zinc as a cofactor for its catalytic activity and indeed contacts between divalent ions and close templates agree very well on positions His56, His58, Asp60, Tyr61, His116, Asp141 and His192.
The consensus form 18 valid protein-ligand interactions produce the following candidate positions: His58, Asp60, His116, Asp141 and His192.

PFRMAT FN
TARGET T0633
AUTHOR 7656-5034-1890
REMARK Sequence consensus of contacts between homologous structures and ligands
METHOD pGenTHREADER and PDBSum and CSA data mining.
MODEL 1
Binding site: 56, 58, 60, 61, 116, 141, 192
END

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« This page (revision-1) was last changed on 28-Jul-2010 11:52 by UnknownAuthor