Domenico:
This target is distantly related to T0591 and T0515 and belongs to the Pyridoxal phosphate-dependent transferase family. The predicted catalytic site is made up of Phe99, Asp169 and Lys197. The binding site for PLP can be predicted fairly accurately because of the strong consensus, including Tyr47, Gly75, Ile76, Asp77, Phe99, Ala141, Asn145, Asp169, Thr171, Tyr172, Ser194, Ser196, Lys197 and Arg205.
Cation interactions are invalid, while the consensus of 3 out of four peptides bound to close templates consists of Tyr47, Phe99, Asn145 and Arg313.

PFRMAT FN
TARGET T0636
AUTHOR 7656-5034-1890
REMARK Sequence consensus of contacts between homologous structures and ligands
METHOD pGenTHREADER and PDBSum and CSA data mining.
MODEL 1
Binding site: 47, 75, 76, 77, 99, 141, 145, 169, 171, 172, 194, 196, 197, 205, 313
END

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